No one knows exactly what causes cold urticaria. Certain people appear to have very sensitive skin cells, due to an inherited trait, a virus or an illness. In the most common forms of this condition, cold triggers the release of histamine and other chemicals into the bloodstream.
What cancers cause cold urticaria?
The most common cause of secondary acquired cold-induced urticaria is primary and secondary cryoglobulinemia (e.g. chronic lymphocytic leukemia, lymphosarcoma, leukocytoclastic vasculitis, hepatitis C virus infection, and angioimmunoblastic lymphadenopathy) based on case reports [23,24,25,26,27,28].
Why does cold urticaria happen?
Cold urticaria is caused by exposure to cold. Why the cold stimulus causes the activation of mast cells and the subsequent release of histamine, and other inflammatory mediators remain unknown. Cold urticaria may be primary (idiopathic) or secondary to an underlying haematologic (blood condition) or infectious disease.