Question: Why do periods hurt so much on the first day?

This pain is caused by natural chemicals called prostaglandins that are made in the lining of the uterus. Prostaglandins cause the muscles and blood vessels of the uterus to contract. On the first day of a period, the level of prostaglandins is high.

What is the most painful day of your period?

The levels of pain can vary in primary dysmenorrhoea, she says. Typically, the pain has a regular pattern, beginning just before or as the period begins. It usually lasts for 1-3 days, but is most severe during the first or second day of the period.

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