ACE is primarily localized on the lumenal side of the vascular endothelium. The lung, which has a vast surface area of vascular endothelium, is rich in ACE. Additionally, ACE is present in other organs including kidney, heart, brain, and striated muscle skin, as it is a part of local RAASs.
Is ACE found in the kidney?
ACE is found in the kidney and angiotensin II has many effects on the kidney.
Where is ACE2 located in the cell?
The most remarkable finding was the surface expression of ACE2 protein on lung alveolar epithelial cells and enterocytes of the small intestine. Furthermore, ACE2 was present in arterial and venous endothelial cells and arterial smooth muscle cells in all organs studied.
What produces ACE enzyme?
The liver creates and releases a protein called angiotensinogen. This is then broken up by renin, an enzyme produced in the kidney, to form angiotensin I. This form of the hormone is not known to have any particular biological function in itself but, is an important precursor for angiotensin II.
What is normal range for ACE?
Normal Results Adults have an ACE level less than 40 micrograms/L. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
What does ACE do in the body?
Angiotensin-converting enzyme (ACE) inhibitors are medications that help relax the veins and arteries to lower blood pressure. ACE inhibitors prevent an enzyme in the body from producing angiotensin II, a substance that narrows blood vessels.